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Domino's Pizza Locations

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More About Domino's in San Antonio

Pizza in 78221: Tasty & Fresh From the Oven!

When you're craving a heavenly slice of cheesy, meaty, veggie-loaded goodness, we know your tastebuds don't want just any old pizza in 78221. You're looking for a flavorful pizza with a freshly made tomato sauce, generous heaps of mozzarella, expertly diced pepperoni, and a hand-tossed crust that's both chewy and crispy. You want only the best pizza. You want Domino's.

At Domino's in 78221, it's never been easier to get the fast and fresh pizza you want. Order your pizza online or over the phone, or stop by and place a carryout order at the Domino's nearest you.

Get started by selecting your favorite crust. Choose from a hand-tossed crust that's overflowing with buttery flavor, a pan crust featuring two huge layers of cheese, a crispy thin crust, or a gluten-free pizza crust! Then, choose your sauce and your favorite pizza toppings. Whether you're a freak for sausage and mushrooms or love sweet pineapple and tangy feta cheese, your neighborhood Domino's has it all!

There are more than 34 million ways to make a single Domino's pizza, which means you can be sure we've got a slice that suits your tastes. No matter how unique they are! Build your own pizza from bottom to top or choose one of our many crowd-pleasing specialty pizzas, like the ever popular Ultimate Pepperoni, MeatZZa™, or Cali Chicken Bacon Ranch, and have it delivered hot and fresh to your doorstep, today!

Like A Butler, But For Pizza: 78221 Pizza Delivery

When you order from your 78221 Domino's, you'll see that we're pretty serious about pizza delivery. In fact, we'll make you a promise. We guarantee that your pizza will arrive hot and fresh, right from our toasty oven to your doorstep. Can't wait for your pie to arrive? Use our patented Pizza TrackerⓇ system and follow your pizza order as it's prepped, baked, and headed out the door for delivery... and try to keep your drool from falling onto your keyboard or phone in the meantime.

Wings, Sandwiches, Desserts & Pizza Takeout in 78221

You already know we deliver pizza, but did you know we rock at fast pizza takeout in 78221? Feel free to order from our pizza menu or take home something more! Satisfy everyone's cravings with one of our handcrafted sandwiches, oven-baked pastas, bread bites, salads, and even mouth-watering desserts like chewy cookies and chocolatey brownies.

We have over 12,000 stores in more than 80 countries, which means we know quality and customer service. Our mission is to be San Antonio's best pizza delivery company and everything we do reflects this commitment. You'll witness it in the way our delivery drivers take care of your order and you'll taste it in every bite of pizza you eat. It's time to curb your hunger! Order online, use our free smartphone app, or call your local Domino's restaurant in 78221 for super fast and delicious pizza delivery and carryout today! We may be more than 56 years old, but we aren't just any old 78221 pizza restaurant. Domino's is your go-to pizza place in 78221!