Domino's Pizza - Mount Vernon

321 S Main St

Mount Vernon, Ohio 43050 | (740) 397-3151
  • Mon-Thu: 10 am to 1 am
  • Fri-Sat: 10 am to 2 am
  • Sun: 10 am to 1 am
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More About Domino's on Main St

Order Fresh Handcrafted Pizza at 321 S Main St

When you're craving a mouthwatering slice of cheesy, meaty goodness, we know you're not craving just any old pizza in Mount Vernon. You want a scrumptious pizza prepared with a flavorful tomato sauce, perfectly diced pepperoni, heaping piles of mozzarella cheese, and a hand-tossed crust that's crunchy, crispy, and chewy. You want only the best pizza. You want Domino's.

At Domino's on Main St, we make it easy to get exactly what you want: pizza that's fast and fresh. Visit us in person to place a takeout order, call (740) 397-3151, or order your pizza online!

Get started by picking one of our homemade crusts, including a fluffy, seasoned hand-tossed crust, a gluten-free crust, a pan crust featuring two monstrous layers of cheese, or even a crispy thin pizza crust! Then, choose your sauce and your favorite pizza toppings. Whether you're a freak for sausage and mushrooms or love sweet pineapple and tangy feta cheese, you can make your dreams come true at your local Domino's!

We've got slices to suit any taste. How do we know? Because there are more than 34 million ways to craft a single Domino's pizza. Customize your pizza from crust to sauce or choose from one of our most-loved specialty pizzas, like the popular MeatZZa™, Honolulu Hawaiian, or Memphis BBQ Chicken, and have it delivered to your door today, fast!

Order Mount Vernon Pizza Delivery Near Main St

At your Domino's on Main St, we don't take pizza delivery lightly. In fact, we guarantee your pizza will arrive hot and fresh, right from our oven to your door. Stay up to date with the status of your order using our custom made TrackerⓇ. Enter in your phone number online and follow the progress of your pizza order from the moment you place it until it arrives at your door... and try not to drool on your keyboard while you wait.

Call (740) 397-3151 or order pizza delivery online now! Why keep your hunger waiting any longer?

Nearby Points of Interest


  • CMH


  • Mount Vernon Nazarene University

High Schools

  • Knox County Career Center