Domino's Pizza - Sikeston

503 S Main St

Sikeston, Missouri 63801 | (573) 471-2667
  • Mon-Thu: 10 am to 12 am
  • Fri-Sat: 10 am to 1 am
  • Sun: 10 am to 12 am
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More About Domino's on Main St

Destination? Delicious Pizza at 503 S Main St

When your stomach grumbles for a slice of meaty, veggie-loaded, cheesy goodness, we know you're not craving any old pizza in Sikeston. You want a heavenly pizza topped with a robust tomato sauce, expertly sliced pepperoni, heaping piles of melted mozzarella and a hand-tossed crust that's crunchy, crispy, and chewy. You want an undeniably good pizza. You want Domino's.

At Domino's on Main St, we make it fast and easy to get the fresh pizza you're craving. Stop by to place a takeout order, order your pizza online, or give us a call at (573) 471-2667!

Start off by picking from our menu of crusts. Choose a fluffy, hand-tossed crust that's dusted with garlic seasonings and buttery flavor, a gluten-free crust, a pan crust featuring two monstrous layers of cheese, or even a crispy thin pizza crust! And then, select your sauce and start loading up on the toppings of your choice. Whether you're a serious fan of mushrooms and spinach or love spicy pepperoni and tangy asiago cheese, your pizza dreams can come true at your local Domino's.

There are more than 34 million ways to make a single Domino's pizza, which means you can be sure we've got a slice that suits your tastes. No matter how unique they are! From its sauce to its size, build your own pizza or choose from one of our famous specialty pizzas, like the ever popular Buffalo Chicken, Pacific Veggie, or Ultimate Pepperoni and have it delivered hot and fresh to your doorstep, fast!

Order Sikeston Pizza Delivery Near Main St

At your Domino's on Main St, we take pizza delivery pretty seriously. In fact, we promise your pizza will arrive hot and fresh at your door, right out of our oven. Can't wait for your pie to arrive? Use our patented Pizza TrackerⓇ system and follow your pizza order as it's prepped, baked, and headed out the door for delivery... and in the meantime, try not to drool on your phone or computer.

Order online or call (573) 471-2667 now for pizza delivery near you. Our delivery experts are fast and our pizzas are fresh, just the way you like it!

Nearby Points of Interest


  • MEM

High Schools

  • New Dawn School
  • Scott County Central High School